publications

Mlost J, Kostrzewa M, Malek N, Starowicz K. Molecular Understanding of the Activation of CB1 and Blockade of TRPV1 Receptors: Implications for Novel Treatment Strategies in Osteoarthritis. Int J Mol Sci. 2018 Jan 24;19(2). pii: E342. https://www.ncbi.nlm.nih.gov/pubmed/29364174

Korostynski M, Malek N, Piechota M, Starowicz K. Cell-type-specific gene expression patterns in the knee cartilage in an osteoarthritis rat model. Funct Integr Genomics. 2018 Jan;18(1):79-87. https://www.ncbi.nlm.nih.gov/pubmed/29134405

Pajak A, Kostrzewa M, Malek N, Korostynski M, Starowicz K. Expression of matrix metalloproteinases and components of the endocannabinoid system in the knee joint are associated with biphasic pain progression in a rat model of osteoarthritis. J Pain Res. 2017 Aug 21;10:1973-1989 https://www.ncbi.nlm.nih.gov/pubmed/28860852

Starowicz K, Finn DP.  Cannabinoids and Pain: Sites and Mechanisms of Action. Adv Pharmacol. 2017;80:437-475 https://www.ncbi.nlm.nih.gov/pubmed/28826543

Korostyński M, Małek N, Piechota M, Starowicz K. Blood Transcriptional Signatures for Disease Progression in a Rat Model of Osteoarthritis. Int J Genomics. 2017;2017:1746426 https://www.ncbi.nlm.nih.gov/pubmed/28758108

Luongo L, Starowicz K, Maione S, Di Marzo V. Allodynia Lowering Induced by Cannabinoids and Endocannabinoids (ALICE). Pharmacol Res. 2017, 119:272-27722 https://www.ncbi.nlm.nih.gov/pubmed/28237514 

Malek N, Starowicz K.  Dual-Acting Compounds Targeting Endocannabinoid and Endovanilloid Systems-A Novel Treatment Option for Chronic Pain Management. Front Pharmacol. 2016; 7:257 https://www.ncbi.nlm.nih.gov/pubmed/27582708

Malek N, Kostrzewa M, Makuch W, Pajak A, Kucharczyk M, Piscitelli F, Przewlocka B, Di Marzo V, Starowicz K.  The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic pain. Pharmacol Res. 2016; 111:251-63. https://www.ncbi.nlm.nih.gov/pubmed/27326920

Malek N, Popiolek-Barczyk K, Mika J, Przewlocka B, Starowicz K.  Anandamide, Acting via CB2 Receptors, Alleviates LPS-Induced Neuroinflammation in Rat Primary Microglial Cultures. Neural Plast. 2015;2015:130639. http://www.ncbi.nlm.nih.gov/pubmed/26090232

Malek N, Mrugala M, Makuch W, Kolosowska N, Przewlocka B, Binkowski M, Czaja M, Morera E, Di Marzo V, Starowicz K. A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis. Pain. 2015 May;156(5):890-903. http://www.ncbi.nlm.nih.gov/pubmed/25719612

Luongo L, Malcangio M, Salvemini D, Starowicz K. Chronic pain: new insights in molecular and cellular mechanisms. Biomed Res Int. 2015;2015:676725. http://www.ncbi.nlm.nih.gov/pubmed/25879035

Malek N, Pajak A, Kolosowska N, Kucharczyk M, Starowicz K. The importance of TRPV1-sensitisation factors for the development of neuropathic pain. Mol Cell Neurosci. 2015 Mar;65:1-10. http://www.ncbi.nlm.nih.gov/pubmed/25662734

Malek N, Kucharczyk M, Starowicz K. Alterations in the Anandamide Metabolism in the Development of Neuropathic Pain. Biomed Res Int. 2014;2014:686908. http://www.ncbi.nlm.nih.gov/pubmed/25276812

Starowicz K, Di Marzo V. Non-psychotropic analgesic drugs from the endocannabinoid system:  “magic bullet” or “multiple-target” strategies?” Eur J Pharmacol. 2013 Sep 15;716(1-3):41-53. http://www.ncbi.nlm.nih.gov/pubmed/23500197

Starowicz K, Makuch W, Korostynski M, Malek N, Slezak M, Zychowska M, Petrosino S, De Petrocellis L, Cristino L, Przewlocka B Di Marzo V. Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism., PLoS One. 2013;8(4):e60040. http://www.ncbi.nlm.nih.gov/pubmed/23573230

Starowicz K, Makuch W, Osikowicz M, Piscitelli F, Petrosino S, Di Marzo V, Przewlocka B. Spinal anandamide produces analgesia in neuropathic rats: possible CB(1)- and TRPV1-mediated mechanisms. Neuropharmacology. 2012 Mar;62(4):1746-55. http://www.ncbi.nlm.nih.gov/pubmed/22178705

De Petrocellis L, SchianoMoriello A, Imperatore R, Cristino L, Starowicz K, Di Marzo V. A re-evaluation of 9-HODE activity at TRPV1 channels in comparison to anandamide: enantioselectivity and effects at other TRP channels and in sensory neurons. Br J Pharmacol. 2012 Dec;167(8):1643-51. http://www.ncbi.nlm.nih.gov/pubmed/22861649

Starowicz K, Przewlocka B. Modulation of neuropathic-pain-related behavior by the spinal endocannabinoid/endovanilloid system. Phil. Trans. R. Soc. B. 2012 367, 3286-3299. http://www.ncbi.nlm.nih.gov/pubmed/23108547