publications

Pajak A, Kostrzewa M, Malek N, Korostynski M, Starowicz K Expression of matrix metalloproteinases and components of the endocannabinoid system in the knee joint are associated with biphasic pain progression in a rat model of osteoarthritis. J Pain Res. 2017 Aug 21;10:1973-1989 https://www.ncbi.nlm.nih.gov/pubmed/28860852

Starowicz K, Finn DP.  Cannabinoids and Pain: Sites and Mechanisms of Action. Adv Pharmacol. 2017;80:437-475 https://www.ncbi.nlm.nih.gov/pubmed/28826543

Korostyński M, Małek N, Piechota M, Starowicz K. Blood Transcriptional Signatures for Disease Progression in a Rat Model of Osteoarthritis. Int J Genomics. 2017;2017:1746426 https://www.ncbi.nlm.nih.gov/pubmed/28758108

Luongo L, Starowicz K, Maione S, Di Marzo V. Allodynia Lowering Induced by Cannabinoids and Endocannabinoids (ALICE). Pharmacol Res. 2017, 119:272-27722 https://www.ncbi.nlm.nih.gov/pubmed/28237514 

Malek N, Starowicz K.  Dual-Acting Compounds Targeting Endocannabinoid and Endovanilloid Systems-A Novel Treatment Option for Chronic Pain Management. Front Pharmacol. 2016; 7:257 https://www.ncbi.nlm.nih.gov/pubmed/27582708

Malek N, Kostrzewa M, Makuch W, Pajak A, Kucharczyk M, Piscitelli F, Przewlocka B, Di Marzo V, Starowicz K.  The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic pain. Pharmacol Res. 2016; 111:251-63. https://www.ncbi.nlm.nih.gov/pubmed/27326920

Malek N, Popiolek-Barczyk K, Mika J, Przewlocka B, Starowicz K.  Anandamide, Acting via CB2 Receptors, Alleviates LPS-Induced Neuroinflammation in Rat Primary Microglial Cultures. Neural Plast. 2015;2015:130639. http://www.ncbi.nlm.nih.gov/pubmed/26090232

Malek N, Mrugala M, Makuch W, Kolosowska N, Przewlocka B, Binkowski M, Czaja M, Morera E, Di Marzo V, Starowicz K. A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis. Pain. 2015 May;156(5):890-903. http://www.ncbi.nlm.nih.gov/pubmed/25719612

Luongo L, Malcangio M, Salvemini D, Starowicz K. Chronic pain: new insights in molecular and cellular mechanisms. Biomed Res Int. 2015;2015:676725. http://www.ncbi.nlm.nih.gov/pubmed/25879035

Malek N, Pajak A, Kolosowska N, Kucharczyk M, Starowicz K. The importance of TRPV1-sensitisation factors for the development of neuropathic pain. Mol Cell Neurosci. 2015 Mar;65:1-10. http://www.ncbi.nlm.nih.gov/pubmed/25662734

Malek N, Kucharczyk M, Starowicz K. Alterations in the Anandamide Metabolism in the Development of Neuropathic Pain. Biomed Res Int. 2014;2014:686908. http://www.ncbi.nlm.nih.gov/pubmed/25276812

Starowicz K, Di Marzo V. Non-psychotropic analgesic drugs from the endocannabinoid system:  “magic bullet” or “multiple-target” strategies?” Eur J Pharmacol. 2013 Sep 15;716(1-3):41-53. http://www.ncbi.nlm.nih.gov/pubmed/23500197

Starowicz K, Makuch W, Korostynski M, Malek N, Slezak M, Zychowska M, Petrosino S, De Petrocellis L, Cristino L, Przewlocka B Di Marzo V. Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism., PLoS One. 2013;8(4):e60040. http://www.ncbi.nlm.nih.gov/pubmed/23573230

Starowicz K, Makuch W, Osikowicz M, Piscitelli F, Petrosino S, Di Marzo V, Przewlocka B. Spinal anandamide produces analgesia in neuropathic rats: possible CB(1)- and TRPV1-mediated mechanisms. Neuropharmacology. 2012 Mar;62(4):1746-55. http://www.ncbi.nlm.nih.gov/pubmed/22178705

De Petrocellis L, SchianoMoriello A, Imperatore R, Cristino L, Starowicz K, Di Marzo V. A re-evaluation of 9-HODE activity at TRPV1 channels in comparison to anandamide: enantioselectivity and effects at other TRP channels and in sensory neurons. Br J Pharmacol. 2012 Dec;167(8):1643-51. http://www.ncbi.nlm.nih.gov/pubmed/22861649

Starowicz K, Przewlocka B. Modulation of neuropathic-pain-related behavior by the spinal endocannabinoid/endovanilloid system. Phil. Trans. R. Soc. B. 2012 367, 3286-3299. http://www.ncbi.nlm.nih.gov/pubmed/23108547